KİŞİSEL BİLGİLER

Medeni Durumu : Evli , 2 çocuklu
İş Adresi : Haliç Üniversitesi Okmeydanı Yerleşkesi - Fen Edebiyat Fakültesi Moleküler Biyoloji ve Genetik Bölümü - Şişli – İstanbul
Telefon : (İş) 2122754040  Dahili : 1123    
E-Posta : mericaltinoz@halic.edu.tr

EĞİTİM

Lisans : İstanbul Üniversitesi , İstanbul Tıp Fakültesi, 1993-1997
Yüksek Lisans : İstanbul Üniversitesi , İstanbul Tıp Fakültesi, 1997-2001
Doktora : McGill Üniversitesi, Montreal, Canada , İmmünoloji, Nöro-immünoloji, 2001-2004

ÜYELİKLER

Istanbul Chamber of Medical Doctors

İŞ TECRÜBELERİ

Education & Job Experience:

2006 Jan – Current : Lecturer and Research Associate of Molecular Biology and Genetics in Halic
University

2004 Apr- 2005 Dec : Emergency triage doctor and GP in Istanbul Memorial Hospital
GP in our Children Leukemia Foundation

2004 Mar – 2001 Sep : Postdoctoral research fellow in Montreal Neurological Institute, McGill University,
Canada

2001 Mar – 2000 Mar : Internship- Istanbul Medical Faculty, Istanbul University

1999 – 1993 : Student at Istanbul Medical School, Istanbul University*
* 1997-1998 : Research assistant in Dana Farber Cancer Institute and Brigham and Women's
Hospital at Harvard Medical School

ARAŞTIRMA DENEYİMİ

1993-1995 : Basic Cell Culture Techniques Under Supervision of Prof. Ayhan Bilir at the Histology and Embryology Department of Istanbul Medical School

1996: Microparticle enzyme immuno-assay of cancer markers under supervision of Prof. Nejat Dalay and Prof. Vildan Yasasever at Institute of Oncology of Istanbul University

1997: Ibuprofen inhibition of nf-kappaB and radiation sensitization of human prostate cancer, EMSA assay of nf-kappaB transcription factor - under supervision of Prof. Brendan Price at DFCI of Harvard Medical School

1998: Eryhtropoietin activation of nf-kappaB and protection against nitridergic stress in neuronal cell cultures under supervision of Prof. Stuart Lipton at Brigham and Women's Hospital of Harvard Medical School

2001-2004: 3D-spheroid culturing of human glioma, assessment of glioma growth and invasion, time-lapse video-microscopy, gel zymogen assay of metalloproteases, CNPase (oligodendroglial marker involved in myelin synthesis) western blots, immuno-fluorescence / FACS assays of apoptosis, investigation of the role of progesterone and dexamethasone on human glioma invasion

KAZANILAN BURS VE ÖDÜLLER

2009 Selected by Who's Who of Marquis to be a member of Who's Who in Medicine

2001 Grant for Post-doctorate Fellowship of McGill University, Canada

1997 First place awarded to “The possible regulatory effects of retinoids on the proliferation
and Leukemia Inhibitory Factor release of endometrial and tubal epithelia.” in the medical
category of TUBITAK* project competiton

*TUBITAK is the official scientific research council of Turkey

1993 Participation in the invitational cultural program of the German Ministry of Culture
because of exceptional success in the German language in high school

1993 Qualified for high school senior year education in the U.S.A. as a result of
achievement in the examination for AFS International/Intercultural Programs

1993 Turkish Universities Student Selection Examination – Ranked in %0.05
Turkish Universities Student Placement Examination – Ranked in %1

1993 German Language Diploma (Deutsches Sprachdiplom) from German Ministry of Culture

1991 Government letter of achievement awarded by the prime minister of Turkey to the
project “Effects of N-nitrosopyrolidine on membrane ganglioside profile of rat
small intestine” at the second Congress of Inventors and Researchers of Turkey

YÖNETTİĞİ/GÖREV YAPTIĞI PROJELER

Medroxyprogesterone inhibition of glioma growth and induction of chemo-sensitization

Acetaminophen, nf-kappaB and chemotherapy sensitivity of human MDAH2774 ovarian cancer cells

Noscapine and diltiazem induced growth inhibition and taxane sensitization of glioma

Aspirin modification of histone acetylation and Hemoglobin F synthesis (current)

Analysis of 3800-years old brains from Seyitomer Hoyuk Archaeological Excavation Site (currently ongoing)

Cultivation and genetic analysis of 2500-years old lentils from Seyitomer Hoyuk Archaeological Excavation Site (currently ongoing)

ÖĞRETİM DENEYİMİ

Biochemistry (Class 1) Lectures Given to the Nursing School of Halic University

Cell Biology (Class 2), Physiology (Class 2), Genetic Bases of Physiology and Endocrinology (Class 3), Molecular Microbiology (Class 4), Immunology (Class 4) Lectures Given to Molecular Biology and Genetics Students of Halic University

YÖNETİLEN TEZLER

Medroxyprogesterone modification of C6 glioma angiogenesis (by Engin Ozar, MD, MSc neurosurgeon)

Acetaminophen modification of breast tumor chemo-sensitivity (by Ayse D Guner, MD, PhD, MSc, histology doctorate and anesthesiologist)

Hemoglobin Electrophoresis in Bipolar Disorder: Analysis of the Utility Possibilities of Hemoglobin F and Hemoglobin A2 in Bipolar Disorder as Biological Markers (by Bahri İnce, MD, Bakırkoy Mental State and Psychiatry Hospital, Psychiatry Residency Thesis - 2010)

ULUSLARARASI TOPLANTILAR

1- Palayoor S.T., Altinoz MA, Bump E.A., Coleman C.N. : Combined antitumor activity of radiation and Ibuprofen in human prostate cancer cells in an in vitro growth delay model. 10th International Conference on Chemical Modifiers of Cancer Treatment, Clearwater, Florida, USA, January 1998

2- Altinoz MA, Taskin MM, Bilir A, Aydiner A,Ozar E, Kara I: Evaluating the role of chemoendocrine treatment for malignant glial tumors in C6 astrocytoma cultures. 12th National Congress of Turkish Neurosurgical Society, Antalya Turkey, 1999 (In Turkish)

3- Taskin M, Ozar E, Altinoz MA, Bilir A, Ozdemir U : Medroxyprogesterone acetate inhibits growth of astrocytoma cells in vitro . 11th European Congress of Neurosurgery- European association of neurosurgical societies, Copenhagen Denmark, 1999, ss 120.5

4- Altinoz MA, Del Maestro R, Nalbantoglu J: Noscapine and diltiazem differentially modulate C6 glioma sensitivity to taxol and radiation induced growth suppression in vitro. Canadian Neuro-oncology 10th Biennial Meeting, May 3-5, 2002

5- Altinoz MA, Del Maestro R, Nalbantoglu J: Medroxyprogesterone and 5-FU interactions in inhibiting growth and invasion of C6 glioma cells in spheroid culture. Canadian Neuro-oncology 10th Biennial Meeting, May 3-5, 2002, URL: http://neuro-oncology.mc.duke.edu

6- Altinoz MA, Del Maestro R, Nalbantoglu J: Chemotherapy and medroxyprogesterone induced cell death patterns in C6 glioma occur with distinct ultrastructural features in vitro. Canadian Neuro-oncology 10th Biennial Meeting, May 3-5, 2002

7- Altinoz MA, Sav A, Ince B, Dincer A, Cengiz S, Yazici Z, Altuncul H, Bilgen AN: 3800-year-old brain from a Bronze Age settlement in Kutahya, West Anatolia: remarkable preservation of the brittle double-bond fatty acids in a special earth containing alkali earth elements and boron. XVIIth International Congress of Neuropathology September 11 - 15, 2010, Salzburg, Austria

8- Altınöz MA, Sav A, İnce B, Dinçer A, Bilgen AN: A 3800 Yrs Old Brain: Looking to The History In The Light of Macroscopical and Microscopical Anatomy and Computer Tomography, THE IIIrd INTERNATIONAL SYMPOSIUM of ARCHAEOLOGY (Archaeological Research in Western Central Anatolia), Dumlupinar University, 8th - 9th March 2010

9- Altınöz MA, İnce B, Yazıcı Z, Cengiz S, Altunçul H, Bilgen AN: Could a 3800-yrs old brain still exert traces of life? Analysis on the bases of organic lipids, DNA and trace Elements. THE IIIrd INTERNATIONAL SYMPOSIUM of ARCHAEOLOGY (Archaeological Research in Western Central Anatolia), Dumlupinar University, 8th - 9th March 2010

YAYIN LİSTESİ

International Full Text Publications in Peer-Reviewed Journals & Cited in PubMed and in ISI - International Science Citation Index of Thomson:

1- Altinoz MA, Bilir A, Ozar E, Onar FD, Sav A: Medroxyprogesterone acetate alone or synergistic with chemotherapy suppresses colony formation and DNA synthesis of C6 glioma in vitro. Int J Devl Neurosci 19: 541-547, 2001

2- Altinoz MA, Ozar E, Taskin M, Bozcali E, Bilir A, Altug T, Aydiner A, Sav A: Vascularization pattern of C6 glioma is modified with medroxyprogesterone acetate and ibuprofen in Wistar rat brain. Pathol Oncol Res 7: 185-189, 2001

3- Altinoz MA: Hypothetical clues suggesting that ‘AU’ and ‘UA’ were the first start and stop codons: Is their ancient polimerase extant present as a protein domain fossil in reverse transcriptase and telomerase ? Med Hypotheses 59: 63-67, 2002

4- Bilir A, Altinoz MA, et al. : Autophagy and nuclear changes in FM3A breast tumor after epirubicin, medroxyprogesterone and tamoxifen treatment in vitro Pathobiology 69: 120-6, 2001

5- Bilir A, Altinoz MA, Attar E, Erkan M, Aydiner A: Acetaminophen modulations of chemotherapy efficacy in MDAH 2274 human endometrioid ovarian cancer cell line. Neoplasma 49: 38-42, 2002

6- Altinoz MA: Nf-kappaB, macrophage migration inhibitory factor, and cyclooxygenase inhibitions as likely mechanisms behind the acetaminophen prevention of ovarian cancer. Neoplasma 51(4): 239-47, 2004

7- Bilir A, Guneri A, Altinoz MA : Acetaminophen and DMSO modulate growth and gemcitabine cytotoxicity in FM3A breast cancer cell line in vitro. Neoplasma 51: 460-464, 2004

8- Huang KC, Altinoz M, Larochelle N, Nalbantoglu J: The effect of expression of the coxsackievirus and adenovirus receptor on glioma growth and invasion. Int J Cancer 113: 738-45, 2005

9- Altinoz MA, Santaguida C, Guiot MC, Del Maestro RF: Spinal hemangioblastoma containing metastatic renal cell carcinoma in von Hippel Lindau disease. Case report and Review of Literature. J Neurosurg Spine 3: 495-500, 2005

10- Altinoz MA, Bilir A, Del Maestro RF, Tuna S, Ozcan E, Gedikoglu G: Noscapine and diltiazem augment radiation-induced S-phase arrest and clonogenic death of C6 glioma in vitro. Surg Neurol 65: 478-84, 2006

11- Altinoz MA, Bilir A, Gedikoglu G, Ozcan E, Oktem G, Muslumanoglu M: Medroxyprogesterone and tamoxifen augment anti-proliferative efficacy and reduce mitochondria-toxicity of epirubicin in FM3A tumor cells in vitro. Cell Biol Int 31: 473-81, 2007

12- Altinoz MA, Ozdilli K, Carin MN, Gedikoglu G: Medroxyprogesterone - valproic acid - aspirin. MVA regime to reduce transfusion associated mortality in late-term hemoglobinopathies. Hypothesis and rationale. Med Hypotheses 68: 1342-7, 2007

13- Caner M, Sonmez B, Kurnaz O, Aldemir C, Salar S, Altug T, Bilir A, Altinoz MA: Atorvastatin has cardiac safety at intensive cholesterol-reducing protocols for long term, yet its cancer-treatment doses with chemotherapy may cause cardiomyopathy even under coenzyme-Q10 protection. Cell Biochem Funct 25: 463-72, 2007

14- Altinoz MA, Gedikoglu G, Sav A, Ozcan E, Ozdilli K, Bilir A, Del Maestro RF: Medroxyprogesterone acetate induces C6 glioma chemosensitization via anti-depressant-like lysosomal phospholipidosis/myelinosis in vitro. Int J Neurosci 117: 1465-1480, 2007

15- Gedikoglu G, Altinoz MA. Differentiation-inducing liposoluble vitamin deficiency may explain frequent secondary solid tumors after hematopoietic stem cell transplantation Minireview. Neoplasma 55: 1-9, 2008

16- Altinoz MA, Albayrak SB, Karasu A, Sabanci PA, Imer M, Bilir A. The effects of tibolone on the human primary glioblastoma multiforme cell culture and the rat C6 glioma model. Neurol Res. 2009 Nov;31(9):923-7

17- Tuna S, Altinoz MA, Karasu A, Canbolat A, Bilir A: Selective COX-2 Inhibitor (Rofecoxib) Inhibits Vinorelbine Cytotoxicity in C6 Glioma Cells In Vitro. The Open Pathology Journal, 2009, 3, 22-29

18- Altinoz MA. A Pioneering Clinician Scientist and a NonGovernmental Health Organization: Gunduz Gedikoglu and Our Children Leukemia Foundation - OCLF of Turkey, in Verge of Celebrating Its 30th Anniversary in 2010. International NGO Journal Vol. 4 (6), pp. 305-312

19- Altinoz MA, Sav A, Ince B, Dincer A, Cengiz S, Yazici Z, Altuncul H, Bilgen AN: 3800-year-old brain from a Bronze Age settlement in Kutahya, West Anatolia: remarkable preservation of the brittle double-bond fatty acids in a special earth containing alkali earth elements and boron. Brain Pathology 2010, Vol: 20: 98-99, Suppl. 1

Note: All articles are in peer-reviewed journals. Except the articles 17 and 18, they are also cited in SCI/ISI (Thomson Scientific Index).